Male fertility · Sertoli axis
Sperm Production & Sertoli Function
Curated by Dr. Will (Loop Labs) for you
Your nurse cells are the Sertoli cells — they physically nurse developing sperm. Inhibin B is what they secrete, so it's the most direct read on whether spermatogenesis is actually happening. FSH is the pituitary's drive signal.
- 1Estradiol (sensitive, LC-MS/MS)
Estrogen from aromatized testosterone.
$23.49 - 2FSH
The pituitary's drive signal to the Sertoli cells.
Read WITH Inhibin B: high FSH + low Inhibin B = primary spermatogenic failure.
$3.00 - 3Inhibin B
Secreted directly by your Sertoli (nurse) cells — the best serum marker of active spermatogenesis.
The star. Low Inhibin B = the nurse cells aren't supporting sperm production.
$79.86 - 4LH
Drives the Leydig cells to make testosterone.
$3.00 - 5Prolactin
When high it shuts down the reproductive axis.
$5.66 - 6SHBG
Binding globulin that sets how much testosterone is free.
$5.33 - 7Free testosterone
The bioavailable fraction reaching tissue.
$9.00 - 8Total testosterone
Overall androgen output.
$6.89